Antimalarial activity and biochemical effects of saponin-rich extract of Dianthus basuticus Burtt Davy in Plasmodium berghei-infected mice
| Autor: | Anofi Omotayo Tom Ashafa, Adeyinka Ismaila Adewuyi, Mikhail Olugbemiro Nafiu, Taoheed Adedeji Abdulsalam |
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| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Antioxidant biology medicine.medical_treatment Saponin Defence mechanisms Pharmacology medicine.disease_cause biology.organism_classification chemistry.chemical_compound Complementary and alternative medicine chemistry Chloroquine parasitic diseases medicine Parasite hosting Plasmodium berghei Phenols Oxidative stress medicine.drug |
| Zdroj: | Advances in Traditional Medicine. 22:519-529 |
| ISSN: | 2662-4060 2662-4052 |
| DOI: | 10.1007/s13596-021-00571-w |
| Popis: | Saponin extract from Dianthus basuticus (SEDB), was investigated for its anti-malarial activity and biochemical effects in Plasmodium berghei-infected mice. Thirty mice were divided into six groups of five mice each. The mice in group I (control) were uninfected, while those of groups II–VI were infected intraperitoneally with standard (2 × 107) inoculum of chloroquine sensitive Plasmodium berghei (NK65) parasite. Mice in groups I (control) and II (P. berghei-infected) received 0.5 ml of distilled water orally, while those of groups III–VI were treated orally with 5 mg/kg body weight (b.w) chloroquine and 50, 100 and 150 mg/kg b.w of SEDB respectively for four days following the establishment of parasitaemia. Rectal temperature, body weight, percentage parasitaemia, chemosuppression of parasite multiplication, haematological and biochemical parameters were determined. SEBD at 50, 100 and 150 mg/kg b.w significantly (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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