MICROWAVE-ASSISTED SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL EVALUATION OF PHENYLACRYLAMIDE DERIVATIVES OF TRIAZOLES DERIVED FROM OXAZOLONES

Autor:	Venkat Swamy Puli, Anindita Chatterjee, Venkata Reddy Regalla, Vukoti Kiran Kumar
Rok vydání:	2018
Předmět:	Pharmacology Antioxidant Chemistry medicine.medical_treatment Pharmaceutical Science Biological activity Carbon-13 NMR Antimicrobial Microwave assisted Acetic acid chemistry.chemical_compound medicine Proton NMR Organic chemistry Pharmacology (medical) Biological evaluation
Zdroj:	Asian Journal of Pharmaceutical and Clinical Research. 11:285
ISSN:	2455-3891 0974-2441
DOI:	10.22159/ajpcr.2018.v11i7.25689
Popis:	Objective: The aim of the present study is to synthesize novel phenylacrylamide derivatives as potent bioactive agents.Methods: Novel N-(3-(4H-1,2,4-triazol-4-ylamino)-3-oxo-1-arylidene prop-2-yl) benzimidic acids (7a-c) have been synthesized by the reaction of 4-(arylidene)-2-phenyloxazol-5(4H)-ones (5a-c) with 4-amino-1, 2, 4-triazole (6) in the presence of anhydrous sodium acetate in glacial acetic acid. Titled compounds (7a-c) were obtained in good yields using microwave technology which resulted in dramatic reductions in reaction times leading to the formation of phenylacrylamide derivatives (7a-c) at a faster rate.Results: The structures of the newly synthesized compounds were characterized by Fourier-transform infrared, 1H NMR, 13C NMR, and mass spectral studies. This method can be an efficient method for the synthesis of phenylacrylamide derivatives (7a-c).Conclusion: All the final compounds were screened for their antimicrobial and antioxidant activities and found to be biologically active. Among all the compounds, 7b was found to be potent antimicrobial and antioxidant.
Databáze:	OpenAIRE
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