New metabolites from a Mariana Trench-derived actinomycete Nocardiopsis sp. HDN 17-237
| Autor: | Jun-Xiao Wang, Qianqun Gu, Dehai Li, Qian Che, Tianjiao Zhu, Mudassir Shah, Guojian Zhang, Chunxiao Sun |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Nocardiopsis
food.ingredient Stereochemistry Pharmaceutical Science Secondary metabolite 01 natural sciences Analytical Chemistry chemistry.chemical_compound food Drug Discovery medicine Moiety Pharmacology Strain (chemistry) 010405 organic chemistry Chemistry Organic Chemistry General Medicine Nocardiopsis sp 0104 chemical sciences 010404 medicinal & biomolecular chemistry Complementary and alternative medicine Mariana Trench Molecular Medicine Derivative (chemistry) medicine.drug |
| Zdroj: | Journal of Asian Natural Products Research. 22:1031-1036 |
| ISSN: | 1477-2213 1028-6020 |
| DOI: | 10.1080/10286020.2019.1681411 |
| Popis: | One new β,γ-butenoate derivative phenylbutenote (1), and one new α-pyrone nocapyrone T (2) were isolated from the deep-sea derived actinomycete Nocardiopsis sp. HDN 17-237. Their structures were elucidated by extensive HRMS, IR and NMR analyses. Among them, compound 1 is the first microbial natural products bearing a rare β,γ-butenoate moiety, and compound 2 is the first α-pyrone isolated from strain of Mariana Trench. Compounds 1 and 2 were tested for antioxidant and antibacterial activities, while none of them showed significant activity. |
| Databáze: | OpenAIRE |
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