Synthesis of the aglycones of the ravidomycin family of antibiotics

Autor:	Thomas C. McKenzie, Wesley Hassen, Simon J.F. Macdonald
Rok vydání:	1987
Předmět:	chemistry.chemical_classification Chemistry Stereochemistry medicine.drug_class Antibiotics Ravidomycin chemistry.chemical_compound Aglycone Aniline Bromide medicine Molecular Medicine Derivative (chemistry) Lactone
Zdroj:	Journal of the Chemical Society, Chemical Communications. :1528
ISSN:	0022-4936
DOI:	10.1039/c39870001528
Popis:	The preparation of the aglycones of the ravidomycin family of antibiotics is described, involving the palladium-catalysed coupling of appropriate stannanes with a common tetracyclic bromide (5), the synthesis of which involved Meerwein coupling of an aniline derivative (13) with 2,5-dichloro-1,4-benzoquinone followed by a directed Diels–Alder reaction.
Databáze:	OpenAIRE
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