Abstract PS16-24: Mechanisms underlying obesity-induced enrichment of stem-like breast cancer cells
| Autor: | Christopher Hsu, Shannon Mayberry, Linda A. deGraffenried, Elizabeth Eichman, Brittany Harlow |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Cancer Research. 81:PS16-24 |
| ISSN: | 1538-7445 0008-5472 |
| DOI: | 10.1158/1538-7445.sabcs20-ps16-24 |
| Popis: | Background: Breast cancer represents the most common nonskin malignancy in women worldwide, and most deaths result from metastatic dissemination of the disease. At the same time, studies indicate that obesity induces a stem cell-like phenotype, required for tumor metastases and associated with cancer progression and mortality. Although the precise mechanism behind this reprogramming event remains to be elucidated, preliminary data from our lab demonstrate that the epithelial-mesenchymal transition (EMT) associated with obese conditions is linked to IL-6 mechanistically. Because IL-6 cannot be targeted clinically, it will be of the utmost importance to identify downstream effectors of this IL-6-mediated response. This said, we hypothesize that increased levels of IL-6 in obese conditions are at least partially responsible for inducing a stem cell-like phenotype in breast cancer cells through activation of the Akt-mTOR pathway.Methods: MCF-7 and T47D breast cancer cells will be exposed to sera pooled from normoweight (BMI Citation Format: Shannon Mayberry, Brittany Harlow, Elizabeth Eichman, Christopher Hsu, Linda deGraffenried. Mechanisms underlying obesity-induced enrichment of stem-like breast cancer cells [abstract]. In: Proceedings of the 2020 San Antonio Breast Cancer Virtual Symposium; 2020 Dec 8-11; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2021;81(4 Suppl):Abstract nr PS16-24. |
| Databáze: | OpenAIRE |
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