Creatine phosphate (Neoton) as an additive to St. Thomas' Hospital cardioplegic solution (Plegisol) *1, *2Results of a clinical study
| Autor: | M. Yamada, M. V. Braimbridge, R. A. Jupp, S. Kosker, David J. Chambers, A Crowther |
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| Rok vydání: | 1991 |
| Předmět: |
Pulmonary and Respiratory Medicine
Cardiac function curve medicine.medical_specialty medicine.diagnostic_test business.industry Hemodynamics Infarction General Medicine Perioperative Creatine medicine.disease Phosphocreatine chemistry.chemical_compound chemistry Internal medicine Anesthesia Cardiology Medicine Surgery Sinus rhythm Cardiology and Cardiovascular Medicine business Electrocardiography |
| Zdroj: | European Journal of Cardio-Thoracic Surgery. 5:74-81 |
| ISSN: | 1010-7940 |
| DOI: | 10.1016/1010-7940(91)90004-4 |
| Popis: | Experimentally, creatine phosphate (CP) added to St. Thomas' Hospital cardioplegic solution (STH) improved post-ischaemic recovery of cardiac function in the rat heart. We investigated the effect of adding CP (10.0 mmol/l) to STH. Fifty open-heart surgery patients were randomized into control (STH) and treated (STH + CP) groups (25 per group). Patients underwent (a) monitoring for peri- and postoperative arrhythmias (48-h Holter monitoring). (b) quantitative birefringence assessment of intraoperative myocardial protection in left and right ventricular biopsies sampled at start of bypass (pre-isch.), end of bypass (end-isch.) and after 10 min reperfusion (post-isch.), and (c) measurement of serum creatine kinase-MB isozyme (CK-MB) values for up to 4 days postoperatively; results were assessed with respect to (d) haemodynamics and postoperative clinical outcome. Inotropic support (adrenaline) was required in three patients (12%) from each group; no patient died. All patients required defibrillation, and the number of direct current shocks required for sinus rhythm was the same in each group. The occurrence and incidence of reperfusion-induced arrhythmias were the same in both groups. Serum CK and CK-MB values were similar throughout the sampling period in both groups of patients; one patient in the control group had raised CK-MB levels postoperatively, but perioperative infarction was not indicated by the electrocardiogram.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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