| Autor: |
Parth Chansoria, Emily Bonacquisti, Mairead Heavey, Lina Le, Murali Kannan Maruthamuthu, John Blackwell, Natalie Jasiewicz, Rani S. Sellers, Robert Maile, Shannon Wallet, Thomas Egan, Juliane Nguyen |
| Rok vydání: |
2022 |
| DOI: |
10.1101/2022.11.25.517820 |
| Popis: |
Bioadhesive materials and patches are promising alternatives to surgical sutures and staples. However, many existing bioadhesives do not meet the functional requirements of current surgical procedures and interventions. Here we present a translational patch material that exhibits: (1) instant adhesion to wet tissues (2.5-fold stronger than Tisseel, an FDA-approved fibrin glue), (2) ultra-stretchability (stretching to >300% its original length without losing elasticity), (3) compatibility with rapid photo-projection (in silicodesign and optimization of anisotropic-auxetic patches, we create next generation patches for instant attachment to wet and dry tissues while conforming to a broad range of organ mechanicsex vivoandin vivo. Patches coated with exosomes demonstrate robust wound healing capabilityin vivowithout inducing a foreign body response and without the need for patch removal that can cause pain and bleeding. We further demonstrate a new single material-based, void-filling auxetic patch designed for the treatment of lung puncture wounds.TeaserWe demonstrate a sticky and highly elastic patch with conforming designs for dynamic organ repair. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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