Nitration reactions of astaxanthin and β-carotene by peroxynitrite

Autor:	Hideo Etoh, Tsutomu Hayakawa, Takashi Maoka, Yukimasa Terada, Aditya Kulkarni, Kumiko Ishizuka, Ryo Yoshioka
Rok vydání:	2006
Předmět:	chemistry.chemical_classification medicine.medical_treatment Organic Chemistry Carotene Biochemistry Medicinal chemistry In vitro chemistry.chemical_compound chemistry Astaxanthin Nitration Drug Discovery Nitro medicine Molecule Organic chemistry Carotenoid Peroxynitrite
Zdroj:	Tetrahedron Letters. 47:3637-3640
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2006.03.139
Popis:	The in vitro reactivities of astaxanthin and β-carotene toward peroxynitrite were investigated and the reaction products after scavenging with peroxynitrite were analyzed. A series of carotenoids substituted with nitro group, 14′-s- cis -15′-nitroastaxanthin, 10′-s- cis -11′- cis -11′-nitroastaxanthin, 14′-s- cis -15′-nitro-β-carotene and 10′-s- cis -11′- cis -11′-nitro-β-carotene, were isolated from the reaction products of carotenoids with peroxynitrite. Carotenoids with nitro derivatives were reported for the first time. These results indicated that astaxanthin and β-carotene could catch peroxynitrite or nitrogen dioxide radical ( NO 2 ) in their molecule to form nitrocarotenoids.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5230aad8d1cc85d1e59b9583ab04d841 https://doi.org/10.1016/j.tetlet.2006.03.139 Zobrazit plný text záznamu Full Text from ScienceDirect