A low-cost wearable radiation sensor based on dose response viability of yeast cells

Autor: Tejasvi Parupudi, Manuel Ochoa, Albert Kim, Chang Keun Yoon, Babak Ziaie
Rok vydání: 2016
Předmět:
Zdroj: 2016 IEEE 29th International Conference on Micro Electro Mechanical Systems (MEMS).
DOI: 10.1109/memsys.2016.7421818
Popis: We present the first low-cost wearable radiation sensor that combines a MEMS structure with a microorganism (yeast) and utilizes the dose-response effect of ionizing radiation on yeast cells as a biologically relevant surrogate to measure radiation. Yeast cells are robust microorganisms which are semi-resistant to ionizing radiation. When exposed to radiation, yeast suffers DNA damage, mutations, and/or death, resulting in their decreased viability and ability to ferment a sugar solution. As a result, they provide a physical response (i.e., gas generation) to radiation that is biologically significant (DNA damage). Our dosimeter uses yeast housed in a low cost wearable MEMS structure as a biologically sensitive radiation indicator (canary in the coal mine). The dose response viability of yeast cells and the resulting gas generation in presence of sucrose solution is used to deflect a PDMS membrane and activate an LED indicator. The sensor allows radiation detection with sensitivity of −0.195 mm/decade-rad (1–1000 rad).
Databáze: OpenAIRE