Mannose binding lectin in sera and synovial fluids of patients with rheumatoid arthritis

Autor:	Nada Pilipovic, Goran Radunovic, Zoran Mijušković, Ivan Zgradić, Radmila Nikolajević, Miodrag J. Čolić, Jelica Stojanović, Ljiljana Rackov
Rok vydání:	2003
Předmět:	Chemistry Clinical Biochemistry Inflammation Severe activity bacterial infections and mycoses medicine.disease Complement system Rheumatoid arthritis Immunology medicine Biological fluids Joint cartilage Synovial fluid medicine.symptom Mannan-binding lectin
Zdroj:	Jugoslovenska medicinska biohemija. 22:159-163
ISSN:	1452-8193 0354-3447
DOI:	10.2298/jmh0302159m
Popis:	It has been supposed that low levels of mannose binding lectin (MBL) may be involved in protection of rheumatoid arthritis associated with agalactosil forms of GOIgG immunoglobilins found in rheumatoid synovial fluid and lead to enhanced complement activation and joint cartilage damages. In order to examine the possible link between MBL and mediated complement activation its concentration was measured in sera and synovial fluids of 59 patients classified in moderate and severe activity RA groups and compared with the levels in the same biological fluids of the control group with menisci lesions. No patients had undetectable or lowered MBL in both RA groups. Mean values were either normal or elevated depending on the severity of the disease as a response to inflammation. This finding does not exclude a possible role of MBL-GOIgG mediated complement activation, but provides no support to mitigating RA severity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::522cb9e402121ed9ba34637686d23f5d https://doi.org/10.2298/jmh0302159m Zobrazit plný text záznamu