Synthesis of 1-deoxynojirimycin-trehalamine fused compound and its related compounds

Autor:	Masao Shiozaki, Reiko Yoshiike, Hideyuki Haruyama, Osamu Ubukata
Rok vydání:	1998
Předmět:	chemistry.chemical_compound Chemistry Stereochemistry Organic Chemistry Drug Discovery Enzyme inhibitory Maltase 1-Deoxynojirimycin Biochemistry Combinatorial chemistry Trehalamine
Zdroj:	Tetrahedron Letters. 39:1925-1928
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(98)00049-5
Popis:	1-Deoxynojirimycin-trehalamine fused compound 10 as a mixture together with 11 and its related compound 19 were synthesized The enzyme inhibitory activities of the mixture ( 10 and 11 ), 19 and 20 exhibited IC 50 values of 0.68, 4.2, and 1.5 μg/ml, respectively, toward rat intestinal maltase.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::52289111cb979e503d189202b36d6915 https://doi.org/10.1016/s0040-4039(98)00049-5 Zobrazit plný text záznamu Full Text from ScienceDirect