The metabolism of 2, 5-dimethylhexane in male Fischer 344 rats
| Autor: | M.Paul Serve, D.D. Bombick, Kyung O. Yu, Gayle A. McDonald, David R. Mattie, J. Roberts |
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| Rok vydání: | 1991 |
| Předmět: |
Kidney
medicine.medical_specialty Environmental Engineering Health Toxicology and Mutagenesis Urinary system Metabolite Public Health Environmental and Occupational Health General Medicine General Chemistry Metabolism Mass spectrometry Pollution chemistry.chemical_compound medicine.anatomical_structure Endocrinology chemistry Internal medicine medicine Environmental Chemistry Toxicokinetics Gas chromatography Hyaline |
| Zdroj: | Chemosphere. 22:77-84 |
| ISSN: | 0045-6535 |
| DOI: | 10.1016/0045-6535(91)90266-g |
| Popis: | The urinary metabolites of 2,5-dimethylhexane (2,5-DMH) in male Fischer 344 rats, administered the hydrocarbon by gavage, included 2,5-dimethyl-1-hexanoic acid, 2,5-dimethyl-1,2-hexanediol, 2,5-dimethyl-1,5-hexanediol, 2,5-dimethyl-2,5-hexanediol and 2,5-dimethyl-5-hydroxy-1-hexanoic acid. Metabolism favored the formation of the diols. The metabolites were identified using gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). Histopathologic examination revealed moderate hyaline droplet formation in the renal proximal tubule. |
| Databáze: | OpenAIRE |
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