Viral Vector-Based Modeling of Neurodegenerative Disorders: Parkinson’s Disease
| Autor: | Christopher J. Kemp, D. Luke Fischer, Caryl E. Sortwell, Fredric P. Manfredsson, Sara E. Gombash, Nicole K. Polinski, Megan F. Duffy |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Parkinson's disease viruses Context (language use) Disease Neuropathology Biology medicine.disease biology.organism_classification medicine.disease_cause Virology Parkin Viral vector 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Lentivirus medicine Neuroscience Adeno-associated virus 030217 neurology & neurosurgery |
| Zdroj: | Gene Therapy for Neurological Disorders ISBN: 9781493932702 |
| DOI: | 10.1007/978-1-4939-3271-9_26 |
| Popis: | Gene therapy methods are increasingly used to model Parkinson's disease (PD) in animals in an effort to test experimental therapeutics within a more relevant context to disease pathophysiology and neuropathology. We have detailed several criteria that are critical or advantageous to accurately modeling PD in a murine model or in a nonhuman primate. Using these criteria, we then evaluate approaches made to model PD using viral vectors to date, including both adeno-associated viruses and lentiviruses. Lastly, we comment on the consideration of aging as a critical factor for modeling PD. |
| Databáze: | OpenAIRE |
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