Response to Letter Regarding Article, 'Ventricular Phosphodiesterase-5 Expression Is Increased in Patients With Advanced Heart Failure and Contributes to Adverse Ventricular Remodeling After Myocardial Infarction in Mice'

Autor: Karin R. Sipido, Kenneth D. Bloch, Marijke Pellens, Pieter Vermeersch, Alfons Van Lommel, Cornelius J. Busch, Erik Verbeken, Peter Pokreisz, Paul Herijgers, Luc Schoonjans, Emmanuel S. Buys, Xiaoshun Liu, Olivier Gheysens, Johan Vanhaecke, Hilde Gillijns, Stefan Janssens, Virginie Bito, An Van Den Bergh, Liesbeth Biesmans, Ilse Lenaerts, Glenn Marsboom, Sara Vandenwijngaert
Rok vydání: 2009
Předmět:
Zdroj: Circulation. 120
ISSN: 1524-4539
0009-7322
DOI: 10.1161/circulationaha.109.872986
Popis: We appreciate the comments by Cingolani et al on a possible involvement of Na+/H+ exchanger (NHE-1) in signaling mechanisms downstream of cGMP that can mediate cardioprotection after myocardial infarction. These authors previously reported that NHE-1 expression and activity are increased after myocardial infarction in rats (as a result of myocardial acidosis) and that sustained …
Databáze: OpenAIRE