| Autor: |
Antonio Angelini, Franco Cuccurullo, Francesca Febo, Augusto Di Castelnuovo, Ettore Porreca, Ester Vitacolonna, Giovanna Baccante, Marcello Di Nisio, Concetta Di Febbo |
| Rok vydání: |
2002 |
| Předmět: |
|
| Zdroj: |
American Journal of Hypertension. 15:759-765 |
| ISSN: |
0895-7061 |
| DOI: |
10.1016/s0895-7061(02)02978-3 |
| Popis: |
Background Transforming growth factor-β 1 (TGF-β 1 ) has been demonstrated to be overexpressed in hypertension. Leptin, an adipocyte product, has been shown to play a role in obesity-related hypertension and in vitro studies demonstrated a biologic interaction between leptin and TGF-β 1 . Thus, we evaluate a possible in vivo association between TGF-β 1 , body mass index (BMI), and leptin circulating levels in hypertensive subjects. Methods Blood samples for fasting leptin and TGF-β 1 , were evaluated in 29 overweight, 46 obese, and 29 nonobese hypertensive patients before and after a 12-week calorie-restricted diet. Monocyte cultures were used for in vitro experiments. Results Transforming growth factor-β 1 was significantly elevated in hypertensive obese patients ( n = 46) as compared with TGF-β 1 levels of hypertensive patients with normal BMI ( n = 29) (8. 9 ± 3 ng/mL v 4.4 ± 2; P 1 were associated with BMI and leptin levels in an univariate analysis (r = 0.59, P P 1 (from 8.9 ± 3 ng/mL to 5.3 ± 2.8 ng/mL; P P 1 production and mRNA expression in human monocyte cultures. Conclusions Our data indicate that TGF-β 1 levels are positively associated with BMI and leptin levels in hypertensive patients and suggest that adipose tissue may be an important determinant of TGF-β 1 levels possibly by a leptin-dependent pathway. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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