Synthesis of new 3,4-dihydropyrano[c]chromene derivatives and their evaluation as acetyl cholinesterase inhibitors

Autor:	Hichem Ben Jannet, Younes Bouazizi, Anis Romdhane
Rok vydání:	2014
Předmět:	chemistry.chemical_compound Hydroxylamine Chemistry Organic chemistry Acetyl cholinesterase Reactivity (chemistry) Hydrazine (antidepressant) Piperidine Acetylcholinesterase Malononitrile
Zdroj:	European Journal of Chemistry. 5:457-462
ISSN:	2153-2257 2153-2249
Popis:	2-Amino-4-phenyl-4,5-dihydro-5-oxopyrano[2,3- c ]chromen-3-carbonitrile derivatives (8a-d) have been isolated in good yields by the reaction of corresponding 4-hydroxycoumarin (1) with substituted aldehydes (2a-d) and malononitrile (3) under reflux conditions. The reactivity of α-functionalized iminoethers (9a-d) with hydrazine, hydroxylamine and piperidine was studied. The synthesized compounds were characterized by various techniques including spectroscopy. Compounds 8-11 were also evaluated as potential acetylcholinesterase inhibitors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::51ffe9edf0fa4377ec3e205075fb78cf https://doi.org/10.5155/eurjchem.5.3.457-462.1040 Zobrazit plný text záznamu