Efficient syntheses of 1,2,3,4,4a,5-hexahydro-pyrazino[2,1-c][1,4]benzothiazine-6,6-dioxide

Autor:	Rebecca J. Dooley, Ronald C. Bernotas
Rok vydání:	2010
Předmět:	chemistry.chemical_compound chemistry Cascade reaction Organic Chemistry Drug Discovery Organic chemistry Alkylation Benzothiazine Electrophilic aromatic substitution Biochemistry Medicinal chemistry Chemical synthesis Sulfone
Zdroj:	Tetrahedron. 66:2273-2276
ISSN:	0040-4020
Popis:	Expeditious routes to 1,2,3,4,4a,5-hexahydro-pyrazino[2,1-c][1,4]benzothiazine-6,6-dioxide, a methylenesulfone-constrained arylpiperazine, have been developed. The key step forms the tricyclic system in a cascade of reactions via a 1,4-addition, nitrogen alkylation, and aromatic substitution sequence.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::51fc46cecdb558b3507d1c0b8f20ac71 https://doi.org/10.1016/j.tet.2010.01.092 Zobrazit plný text záznamu Full Text from ScienceDirect