Enantiomeric Composition of Chiral β-Hydroxylamides by1H NMR Spectroscopy Using Chiral Solvating Agent

Autor:	Jean-Claude Cherton, M. Carli, B. Merelli, L. Menguy
Rok vydání:	2008
Předmět:	1h nmr spectroscopy Chemistry Enzymatic hydrolysis Proton NMR Diastereomer Organic chemistry Enantiomer Chiral derivatizing agent Spectroscopy Atomic and Molecular Physics and Optics Analytical Chemistry
Zdroj:	Spectroscopy Letters. 41:361-368
ISSN:	1532-2289 0038-7010
DOI:	10.1080/00387010802371726
Popis:	Studies of the perturbing effect of the trifluoromethylanthryl carbinol used as chiral solvating agent (CSA) upon the 1H NMR spectra of chiral α-O-substituted β-hydroxylamides demonstrated the ability of this fluoroalcohol to afford diastereomeric solvates with these solutes. Thus, for all the tested amides, there is at least one possibility to proceed to their enantiomeric discrimination by 1H NMR using CSA. The method was developed to determine (later and indirectly) a possible chiral recognition during in vitro enzymatic hydrolysis in locust biological tissues of N-acylaziridines conceived as proinsecticides of carboxylic acids, in view to eventually optimize their efficiency.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::51efc0b0cc14e79be0c6058b282cacaf https://doi.org/10.1080/00387010802371726 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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