Binding and Release of FeIII Complexes from Glucan Particles for the Delivery of T 1 MRI Contrast Agents
| Autor: | Eric M. Snyder, Paul J. Cullen, Alexandra E. Dilillo, Akanksha Patel, Janet R. Morrow, Didar Asik |
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| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
chemistry.chemical_classification 010405 organic chemistry Organic Chemistry Maltol Nanoparticle 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Coordination complex 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Drug Discovery Amphiphile Molecular Medicine Chelation Iron complex General Pharmacology Toxicology and Pharmaceutics Fluorescent tag Glucan |
| Zdroj: | ChemMedChem. 15:1050-1057 |
| ISSN: | 1860-7187 1860-7179 |
| Popis: | Yeast-derived β-glucan particles (GPs) are a class of microcarriers under development for the delivery of drugs and imaging agents to immune-system cells for theranostic approaches. However, the encapsulation of hydrophilic imaging agents in the porous GPs is challenging. Here, we show that the unique coordination chemistry of FeIII -based macrocyclic T1 MRI contrast agents permits facile encapsulation in GPs. Remarkably, GPs labeled with the simple FeIII complexes are stable under physiologically relevant conditions, despite the absence of amphiphilic groups. In contrast to the free FeIII coordination complex, the labeled FeIII -GPs have lowered T1 relaxivity and act as a silenced form of the contrast agent. Addition of a fluorescent tag to the FeIII complex produces a bimodal agent to further enable tracking of the nanoparticles and to monitor release. Treatment of the iron-labeled GPs with a maltol chelator or with mildly acidic conditions releases the intact iron complex and restores enhanced T1 relaxation of the water protons. |
| Databáze: | OpenAIRE |
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