Association between FOXP3+ regulatory T-cells and occurrence of peritoneal lesions in women with ovarian endometrioma and dermoid cysts
| Autor: | Khaleque Newaz Khan, Akira Fujishita, Satoshi Teramukai, Akemi Koshiba, Satomi Sakabayashi, Jo Kitawaki, Kazuo Yamamoto, Masahiro Nakashima, Haruo Kuroboshi |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Ovarian Endometrioma Pathology medicine.medical_specialty education.field_of_study 030219 obstetrics & reproductive medicine business.industry Peritoneal fluid Population Endometriosis Obstetrics and Gynecology FOXP3 medicine.disease Menstruation 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Reproductive Medicine Dermoid cyst medicine Immunohistochemistry business education Developmental Biology |
| Zdroj: | Reproductive BioMedicine Online. 38:857-869 |
| ISSN: | 1472-6483 |
| Popis: | Research question Is there any relationship between numbers of FOXP3+ regulatory T-cells (Treg) and occurrence of peritoneal lesions in women with ovarian endometrioma and dermoid cysts? Design Retrospective and prospective case-controlled cohort study. Peritoneal lesions were collected from 27 women with ovarian endometrioma and 25 women with dermoid cysts. Peritoneal fluid was collected from 36 women with ovarian endometrioma and 42 women with dermoid cysts. Tissue expression of Forkhead box P3 (FOXP3), one of the transcription factors of Treg cells, and transforming growth factor-beta (TGF-β) were examined by immunohistochemistry. Interleukin-6 (IL-6) and TGF-β levels in the peritoneal fluid were measured by enzyme-linked immunosorbent assay. Results Ovarian endometrioma cases with coexisting peritoneal lesions were significantly more frequent than dermoid cyst cases with coexistent peritoneal lesions (269/350 [76.9%] versus 74/414 [17.9%]; P Conclusions This study confirms current speculation that endometriosis is related to alteration in Treg cells, causing survival and implantation of ectopic endometrial lesions in women with endometrioma and dermoid cysts. The findings may clarify why only 10% of women in the general population develop endometriosis despite cyclic menstruation with retrograde flow occurring in >90% of women. |
| Databáze: | OpenAIRE |
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