Microbiota Contribute to Obesity-related Increases in the Pulmonary Response to Ozone
| Autor: | David I. Kasahara, Youngji Cho, Vladimir Yeliseyev, Stephanie A. Shore, Curtis Huttenhower, Lynn Bry, Galeb Abu-Ali, Hiroki Tashiro, Jeffrey D. Brand |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Ozone medicine.drug_class Clinical Biochemistry Antibiotics Gut flora 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Microbiome Risk factor Molecular Biology Asthma biology business.industry Cell Biology biology.organism_classification medicine.disease Obesity respiratory tract diseases 030104 developmental biology 030228 respiratory system chemistry Immunology business Airway responsiveness |
| Zdroj: | American Journal of Respiratory Cell and Molecular Biology. 61:702-712 |
| ISSN: | 1535-4989 1044-1549 |
| DOI: | 10.1165/rcmb.2019-0144oc |
| Popis: | Obesity is a risk factor for asthma, especially nonatopic asthma, and attenuates the efficacy of standard asthma therapeutics. Obesity also augments pulmonary responses to ozone, a nonatopic asthma trigger. The purpose of this study was to determine whether obesity-related alterations in gut microbiota contribute to these augmented responses to ozone. Ozone-induced increases in airway responsiveness, a canonical feature of asthma, were greater in obese db/db mice than in lean wild-type control mice. Depletion of gut microbiota with a cocktail of antibiotics attenuated obesity-related increases in the response to ozone, indicating a role for microbiota. Moreover, ozone-induced airway hyperresponsiveness was greater in germ-free mice that had been reconstituted with colonic contents of db/db than in wild-type mice. In addition, compared with dietary supplementation with the nonfermentable fiber cellulose, dietary supplementation with the fermentable fiber pectin attenuated obesity-related increases in the pulmonary response to ozone, likely by reducing ozone-induced release of IL-17A. Our data indicate a role for microbiota in obesity-related increases in the response to an asthma trigger and suggest that microbiome-based therapies such as prebiotics may provide an alternative therapeutic strategy for obese patients with asthma. |
| Databáze: | OpenAIRE |
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