Statins Solubilized in Fish Oil: Versatile and Simple Combinations by Innovative Formulations
| Autor: | Mose Santaniello, Giannini Giuseppe |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Statin
business.industry medicine.drug_class Atorvastatin Hypertriglyceridemia nutritional and metabolic diseases Pharmacology medicine.disease Simvastatin Hyperlipidemia medicine lipids (amino acids peptides and proteins) Rosuvastatin cardiovascular diseases Pitavastatin business Dyslipidemia medicine.drug |
| Zdroj: | Nutrition and Food Technology: Open Access ( ISSN 2470-6086 ). 1 |
| ISSN: | 2470-6086 |
| DOI: | 10.16966/2470-6086.104 |
| Popis: | Dyslipidemia or hyperlipidemia comprised mainly hypertriglyceridemia and/or hypercholesterolemia; it is now well established as their control is considered to have an impact on public health. Therefore, in an overcrowded field to find appropriate answers to lower blood levels of cholesterol and triglycerides, here we report findings of formulation studies, aimed to combine statins and n-3 PUFA, overcoming drawbacks related to solubility and stability. A new formulation has been made creating a solvent system that allows for a complete solubilization of statin drugs such as atorvastatin, rosuvastatin, and pitavastatin. With simvastatin, a preliminary dehydration with molecular sieves was also needed for stability purpose. These findings are of great importance and could be applied widely in all cases where a co-administration of the two active therapeutic ingredients are routinely required. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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