Relationship Between White Matter Microstructure and Hallucination Severity in the Early Stages of Psychosis: A Diffusion Tensor Imaging Study
| Autor: | Atsushi Sakuma, Noriyuki Ohmuro, Kazunori Matsumoto, Hiroaki Tomita, Kazuho Tomimoto, Fumiaki Ito, Yutaro Sato, Koichi Abe, Masahiro Katsura, Kunio Iizuka |
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| Rok vydání: | 2021 |
| Předmět: |
Psychosis
medicine.diagnostic_test Magnetic resonance imaging medicine.disease White matter microstructure 030227 psychiatry White matter 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine medicine.anatomical_structure Nuclear magnetic resonance Schizophrenia medicine Psychology 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Schizophrenia Bulletin Open. 2 |
| ISSN: | 2632-7899 |
| Popis: | Background Diffusion tensor imaging (DTI) studies have investigated the relationship between hallucinations in schizophrenia and white matter (WM) microstructure. However, only a few studies have focused on hallucination severity in the early stages of psychosis, and the involvement of the WM microstructure in the development of hallucinations remains unclear. This study aimed to examine the WM microstructure related to hallucination severity in the early stages of psychosis. Methods DTI analysis using tract-based spatial statistics (TBSS) was applied to 138 participants, consisting of 105 individuals with early stages of psychosis (56 individuals with clinical high risk for psychosis [CHR] and 49 individuals with first-episode psychosis [FEP]) and 33 healthy controls (HCs). Group comparisons of fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) were performed. We examined the association of FA, MD, RD, and AD with hallucination severity in the early stages of psychosis. Results Lower FA and higher MD and RD in multiple WM tracts were observed in the early stages of psychosis compared to HCs. We found an association between hallucination severity and increased MD in the WM tract, consisting mainly of the left superior longitudinal fasciculus (SLF) and inferior fronto-occipital fasciculus (IFOF). Conclusions Our findings indicate that dysconnectivity in brain networks associated with language processing is related to the development of hallucinations. Further studies of the early stages of psychosis are needed to elucidate the mechanism of hallucinations. |
| Databáze: | OpenAIRE |
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