Evolution of a series of non-quinoline leukotriene D4 receptor antagonist; synthesis and sar of benzothiazoles and thiazoles substituted benzyl alcohols as potent LTD4 antagonists

Autor:	C. Rochette, Robert Zamboni, Anthony W. Ford-Hutchinson, Claude Dufresne, Marc Labelle, Deborah Slipetz, C. S. Mcfarlane, Thomas R. Jones, Yves Gareau, Lau Cheuk-Kun, Robert N. Young, L. Charette, Kathleen M. Metters, M. McAuliffe, Nicole Sawyer
Rok vydání:	1995
Předmět:	LTD4 receptor Stereochemistry Organic Chemistry Clinical Biochemistry Quinoline Antagonist Pharmaceutical Science Biochemistry Combinatorial chemistry chemistry.chemical_compound Orally active Leukotriene D4 receptor chemistry Drug Discovery Molecular Medicine Pharmacophore Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 5:1615-1620
ISSN:	0960-894X
DOI:	10.1016/0960-894x(95)00265-u
Popis:	Replacement of the quinoline pharmacophore of verlukast by alkylthiazoles and benzothiazoles has lead to the discovery of a new series of potent and orally active LTD4 receptor antagonists. The synthesis and structure activity relationships of this series of compounds are described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::51c83f99b1039f9d62371191466a6878 https://doi.org/10.1016/0960-894x(95)00265-u Zobrazit plný text záznamu Full Text from ScienceDirect