HPLC determination of the new cardiotropic drug protecor in blood serum of animals

Autor:	S. N. Ptitsina, V. I. Bobrov, M. M. Borisov, I. Kh. Ivanova, L. N. Serov, I. I. Miroshnichenko
Rok vydání:	2006
Předmět:	Pharmacology Drug Drug elimination Chemistry media_common.quotation_subject Pharmacology toxicology Beagle High-performance liquid chromatography Drug pharmacokinetics Blood serum Drug Discovery Blood plasma media_common
Zdroj:	Pharmaceutical Chemistry Journal. 40:683-685
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-006-0219-z
Popis:	An HPLC-based method with ultraviolet detection has been developed for determining the new cardiotropic drug protecor in the blood and applied to monitoring of the drug pharmacokinetics after intravenous administration in experimental animals (rabbits and beagle dogs). Ahigh initial concentration of protecor in the blood plasma, followed by rapid drug elimination has been observed after administration in a single dose to beagles (25 mg/kg) and rabbits (100 mg/kg). The drug half-elimination time was 0.47 and 0.32 h for dogs and rabbits, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::51c782c91ae02db3d69397262b104184 https://doi.org/10.1007/s11094-006-0219-z Zobrazit plný text záznamu Plný text ve formátu PDF