HPLC determination of the new cardiotropic drug protecor in blood serum of animals

Autor: S. N. Ptitsina, V. I. Bobrov, M. M. Borisov, I. Kh. Ivanova, L. N. Serov, I. I. Miroshnichenko
Rok vydání: 2006
Předmět:
Zdroj: Pharmaceutical Chemistry Journal. 40:683-685
ISSN: 1573-9031
0091-150X
Popis: An HPLC-based method with ultraviolet detection has been developed for determining the new cardiotropic drug protecor in the blood and applied to monitoring of the drug pharmacokinetics after intravenous administration in experimental animals (rabbits and beagle dogs). Ahigh initial concentration of protecor in the blood plasma, followed by rapid drug elimination has been observed after administration in a single dose to beagles (25 mg/kg) and rabbits (100 mg/kg). The drug half-elimination time was 0.47 and 0.32 h for dogs and rabbits, respectively.
Databáze: OpenAIRE