Prenylated Chromones from the Fruits of Artocarpus heterophyllus and Their Potential Anti-HIV-1 Activities
| Autor: | Qin-Ting Su, Yu-Tong Xie, Jia-Ming Guo, Yan-Hui Fu, Xiao-Mei Yu, Ling-Yi Kong, Yan-Ping Liu, Lei Qiang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
Anti hiv 1 biology Traditional medicine 010401 analytical chemistry food and beverages General Chemistry Health benefits Moraceae biology.organism_classification 01 natural sciences Tropical fruit 0104 chemical sciences Artocarpus General Agricultural and Biological Sciences Fruit tree 010606 plant biology & botany |
| Zdroj: | Journal of Agricultural and Food Chemistry. 68:2024-2030 |
| ISSN: | 1520-5118 0021-8561 |
| Popis: | Artocarpus heterophyllus (jack tree) is an evergreen fruit tree belonging to the genus Artocarpus (Moraceae), which is widely distributed in subtropical and tropical regions of Asia. Its fruits (jackfruit), well-known as the world's largest tree-borne fruit, are being consumed in our daily diets as a very popular tropical fruit throughout the world and have been confirmed to hold various health benefits. In this study, five new prenylated chromones, artocarheterones A-E (1-5), as well as seven known prenylated chromones (6-12) were purified and isolated from the ripe fruits of A. heterophyllus (jackfruit). Their chemical structures were determined through comprehensive spectroscopic methods. This is the first report on prenylated chromones isolated from A. heterophyllus. The anti-HIV-1 effects of all isolated chromones were assessed in vitro. As a result, prenylated chromones (1-12) showed remarkable anti-HIV-1 effects with EC50 values ranging from 0.09 to 9.72 μM. These research results indicate that the isolation and characterization of these prenylated chromones with remarkable anti-HIV-1 activities from the ripe fruits of A. heterophyllus could be significant to the discovery and development of new anti-HIV-1 drugs. |
| Databáze: | OpenAIRE |
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