Review cyclic peptides on a merry-go-round; towards drug design

Autor:	Theodore Tselios, Minos-Timotheos Matsoukas, Carmen Simal, Anthi Tapeinou
Rok vydání:	2015
Předmět:	chemistry.chemical_classification Drug media_common.quotation_subject Organic Chemistry High selectivity Biophysics Rational design Drug design Biological activity Peptide General Medicine Biochemistry Combinatorial chemistry Cyclic peptide Biomaterials chemistry Peptide ligand media_common
Zdroj:	Biopolymers. 104:453-461
ISSN:	0006-3525
DOI:	10.1002/bip.22669
Popis:	Peptides and proteins are attractive initial leads for the rational design of bioactive molecules. Several natural cyclic peptides have recently emerged as templates for drug design due to their resistance to chemical or enzymatic hydrolysis and high selectivity to receptors. The development of practical protocols that mimic the power of nature's strategies remains paramount for the advancement of novel peptide-based drugs. The de novo design of peptide mimetics (nonpeptide molecules or cyclic peptides) for the synthesis of linear or cyclic peptides has enhanced the progress of therapeutics and diverse areas of science and technology. In the case of metabolically unstable peptide ligands, the rational design and synthesis of cyclic peptide analogues has turned into an alternative approach for improved biological activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::51bfd45177bfdc89dd05c163fceb846d https://doi.org/10.1002/bip.22669 Zobrazit plný text záznamu Plný text