Barakacin: A Thiazolyl-indole Alkaloid Isolated from a Ruminal Pseudomonas sp

Autor:	Imene Zendah, Hartmut Laatsch, Khaled A. Shaaban, Armin Maier, Heinz H. Fiebig, Elisabeth Helmke
Rok vydání:	2012
Předmět:	biology Indole alkaloid Pseudomonas aeruginosa Chemistry Stereochemistry Alkaloid Pseudomonas General Chemistry medicine.disease_cause biology.organism_classification Rumen Glycolipid medicine Fermentation Bacteria
Zdroj:	Zeitschrift für Naturforschung B. 67:417-420
ISSN:	1865-7117 0932-0776
Popis:	A new thiazolyl-indole alkaloid, barakacin (1), has been isolated from the ruminal bacterium Pseudomonas aeruginosa strain ZIO. On the basis of detailed spectroscopic analyses and comparison with the data of related compounds, its structure has been determined as 2-{4-[bis-(1H-indol-3- yl)-methyl]-thiazol-2-yl}-phenol. In addition, the known compounds phenazine-1-carboxylic acid, 3-(hydroxyacetyl)-indole, indole-3-carbaldehyde, and glycolipid A were isolated. The discovery of compounds with a new skeleton emphasizes the importance for exploring new ecological niches like the rumen of bovines for the detection of new natural products. This paper describes the fermentation, isolation, structure elucidation and biological activities of compound 1.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::51b7bf08aa16060b034a6e3c5513aea4 https://doi.org/10.5560/znb.2011-0277 Zobrazit plný text záznamu