Synthesis, Molecular Docking, Cytotoxicity and Antioxidant Activity Evaluation of Isoindoline-1,3-dione Derivatives

Autor:	Raman Mohanapriya, Arulappan Durairaj, Kuruba Bharath Kumar, Subramanian Ramanathan, Asir Obadiah, Suluvoy Jagadish Kumar, Samuel Vasanthkumar, Palanichamy Santhosh Kumar
Rok vydání:	2019
Předmět:	chemistry.chemical_compound 010405 organic chemistry Chemistry General Chemistry Isoindoline 010402 general chemistry Cytotoxicity 01 natural sciences Combinatorial chemistry 0104 chemical sciences
Zdroj:	Asian Journal of Chemistry. 31:2548-2556
ISSN:	0975-427X 0970-7077
DOI:	10.14233/ajchem.2019.22185
Popis:	A variety of amines have been employed to functionalize isobenzofuran-1,3-dione to obtain isoindoline-1,3-dione derivatives in the base free conditions. All the synthesized compounds are screened for their bioactivity through molecular docking, cytotoxicity (against HeLa) and antioxidant activity. ABTS and DPPH are employed to assess the antioxidant activity. Among the synthesized isoindoline-1,3-dione derivatives (3a-k), compound 3e has showed the best antioxidant activity and also exhibited better binding energy when docked with caspase-3 protein. Cytotoxicity of the synthesized compounds was studied against cervical cancer cell line (HeLa) and compound 3e has displayed better activity than other isoindoline derivatives.
Databáze:	OpenAIRE
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