Age increases MCP-1 level in association with bariatric surgery operating time and metabolic risk severity
| Autor: | C. A. McNamara, Jennifer L Kaplan, Jennifer L. Kirby, James C. Garmey, L. Meng, Angela M. Taylor, Steven K. Malin, Peter T. Hallowell |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Nutrition and Dietetics business.industry Endocrinology Diabetes and Metabolism Insulin medicine.medical_treatment Adipose tissue 030209 endocrinology & metabolism Inflammation medicine.disease Surgery 03 medical and health sciences 0302 clinical medicine Insulin resistance Blood pressure medicine 030212 general & internal medicine medicine.symptom Metabolic syndrome business Body mass index Lipoprotein |
| Zdroj: | Obesity Science & Practice. 3:193-200 |
| ISSN: | 2055-2238 |
| Popis: | SummaryObjective Assess the role of inflammation on operating time in younger vs. older bariatric surgery patients. Methods Fifty-five younger (F: 46, Age: 34.9 ± 4.0 years, body mass index [BMI]: 48.2 ± 1.0 kg m−2) and 48 older (F: 34, Age: 57.0 ± 5.1 years, BMI: 46.8 ± 1.0 kg m−2) adults were studied prior to surgery. Blood pressure, glycaemic control (fasting glucose/insulin, HbA1c), lipids (high-density lipoprotein and triglycerides) and inflammation (monocyte chemoattractant protein-1 [MCP-1]) were assessed. Metabolic risk severity z-scores were calculated from clinical outcomes. Omental adipose biopsies were collected at surgery for MCP-1 protein analysis. Operating time was used to characterize surgical difficulty. Results Older vs. younger adults had higher HbA1c (P = 0.03). There was no difference in BMI, lipids, metabolic risk severity or insulin between groups, but operating time was longer in older vs. younger individuals (P = 0.04). Circulating MCP-1 was also elevated in older vs. younger adults (P = 0.04) independent of HbA1c, although this was not explained by omental fat. Nevertheless, serum MCP-1 was associated with increased metabolic risk severity (R = 0.27, P = 0.01). In addition, operating time was linked to HbA1c (R = 0.30, P = 0.01) and omental MCP-1 protein (R = 0.31, P |
| Databáze: | OpenAIRE |
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