Biophysical mechanisms of contact activation of blood-plasma clotting

Autor:	A. N. Sveshnikova, M. A. Panteleev, V. A. Terent’eva
Rok vydání:	2017
Předmět:	0301 basic medicine Factor XII Blood clotting biology Chemistry Biophysics 030204 cardiovascular system & hematology Blood proteins Fibrin 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Contact activation In vivo Blood plasma biology.protein Platelet
Zdroj:	Biophysics. 62:742-753
ISSN:	1555-6654 0006-3509
Popis:	This review considers the biochemical and biophysical mechanisms that trigger blood clotting upon contact of blood with an alien surface and leads via a cascade of enzymatic reactions to fibrin polymerization and the formation of a blood plasma clot, which permeates a primary platelet aggregate to produce a dense hemostatic clot. In spite of the substantial number of experimental and theoretical studies on the subject, there is still no consistent opinion as to what processes occur as the blood plasma contacts a surface. This review discusses the role that plasma protein factor XII and various surfaces play in triggering the contact pathway in vivo and in vitro. Current views of the molecular events that underlie the process are described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::51a25ab4f4ba75a9b336c39e067fa30b https://doi.org/10.1134/s0006350917050232 Zobrazit plný text záznamu Full text from SpringerLink