De novo design of type II topoisomerase inhibitors as potential antimicrobial agents targeting a novel binding region

Autor: Kyle M. Orritt, Lipeng Feng, Juliette F. Newell, Jack N. Sutton, Scott Grossman, Thomas Germe, Lauren R. Abbott, Holly L. Jackson, Benjamin K. L. Bury, Anthony Maxwell, Martin J. McPhillie, Colin W. G. Fishwick
Rok vydání: 2022
Předmět:
Zdroj: RSC Medicinal Chemistry. 13:831-839
ISSN: 2632-8682
Popis: A computational design, make and test strategy was used to identify antibacterial inhibitors of bacterial DNA gyrase and topoisomerase IV, proposed to bind at a novel allosteric site.
Databáze: OpenAIRE