Human ENPP1 gene polymorphism in DKD patients: a hospital-based case control study
| Autor: | Rana Gopal Singh, A. K. Singh, Shri Prakash Singh, Parimal Das, C. S. Azad, S. Chandra, Mritunjai Singh, Praveen C. Pandey |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
education.field_of_study business.industry Endocrinology Diabetes and Metabolism Population Case-control study 030209 endocrinology & metabolism Hospital based medicine.disease 03 medical and health sciences 0302 clinical medicine Polymorphism (computer science) Diabetes mellitus Internal medicine parasitic diseases Genotype Internal Medicine medicine 030212 general & internal medicine Gene polymorphism Allele education business |
| Zdroj: | International Journal of Diabetes in Developing Countries. 41:63-70 |
| ISSN: | 1998-3832 0973-3930 |
| Popis: | The aim of present study was to investigate the association of the ENPP1 (K121Q) gene polymorphism with DKD in eastern Uttar Pradesh population. A total of 162 DKD and 155 apparently healthy controls were enrolled and K121Q polymorphism was determined by PCR-RFLP followed by sequencing. It was observed that genotype KQ was more frequent in patients than controls and allelic frequencies of Q allele were higher in DKD (Q 21.3%) than control (Q 15.81%). It depicted that Q allele may be associated with DKD patient and has more risk in eastern UP population. The study indicated a significant association of KQ polymorphism of the ENPP1 gene with DKD in the eastern Uttar Pradesh population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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