CHANGES IN DOGS DEVOID OF A CELLS1
| Autor: | S. Mariz, J. Frei, Sergio A. Bencosme |
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| Rok vydání: | 1957 |
| Předmět: | |
| Zdroj: | Endocrinology. 61:1-11 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-61-1-1 |
| Popis: | THE recent and excellent reviews of Cavallero (1), Foa (2) and Korp and Le Compte (3), have indicated that the inability to produce complete and permanent destruction of the A cells of the pancreas has greatly hindered our understanding of their function, particularly as a possible site of origin of glucagon. Recently, several substances have been used in an attempt to destroy the A cells, but there is as yet no general agreement on the exact nature of the A cell lesion thus obtained, nor on the effectiveness of these drugs in various animal species (4, 5, 6, 7, 8). The discoveryin our laboratory that the uncinate process of the dog pancreas is normally devoid of A cells, whereas the B and D cells are present (9), and than glucagon is probably absent in this portion of pancreas but abundant in the rest of the organ (10), prompted us to investigate the changes occurring in dogs deprived of their A cells. |
| Databáze: | OpenAIRE |
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