| Autor: |
Daniel P. van Kammen, Theodore A. Hare, Robert M. Post, James C. Ballenger, Stephen R. Marder, D. E. Sternberg, William E. Bunney |
| Rok vydání: |
1980 |
| Předmět: |
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| Zdroj: |
Brain Research Bulletin. 5:731-735 |
| ISSN: |
0361-9230 |
| DOI: |
10.1016/0361-9230(80)90120-3 |
| Popis: |
Cerebrospinal fluid (CSF) GABA levels were determined in the spinal fluid of 17 drug-free schizophrenic patients and of 40 normal volunteers. Following lumbar puncture in fasting patients maintained at bed rest, CSF from the 16th to the 20th cc was collected, placed on ice immediately and frozen at −70°C within one hour. CSF GABA was measured by a modified cation exchange chromatography. Schizophrenic patients showed significantly lower CSF GABA levels (191 ± 9 pmol / ml ) compared to normal controls (233 ± 13 pmol / ml ; p r =0.54) and number of hospitalizations ( r =0.50), but not with severity of psychosis or age of onset. A negative correlation with CSF glucose levels was observed ( r =−0.61). These data suggest that if a GABA deficit is present it only will be observed early in the illness and may disappear with chronicity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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