Evaluation of Serum Interleukin-6 Level in Vitiligo Patients before and after Phototherapy
| Autor: | Ahmed Ayman Mohamed Abd El Hamed, Mamdouh Atiah Mohamed, Amr Mohamed Zaki, Hassan Mamdouh Abd El Aziz |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
medicine.medical_specialty integumentary system biology medicine.diagnostic_test business.industry Clinical course Disease Vitiligo medicine.disease Dermatology Pathogenesis 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Erythrocyte sedimentation rate Genetic predisposition biology.protein medicine Medical history skin and connective tissue diseases Interleukin 6 business 030304 developmental biology |
| Zdroj: | The Egyptian Journal of Hospital Medicine. 77:5276-5278 |
| ISSN: | 2090-7125 |
| DOI: | 10.21608/ejhm.2019.55489 |
| Popis: | Background: Vitiligo is an acquired pigmentary disorder of the skin, resulting from a loss of functioning epidermal melanocytes. Multiple pathogenetic factors have been proposed, including the neural theory, genetic predisposition and impaired anti-oxidative defense. Objective: To evaluate the role of interleukin-6 in pathogenesis of vitiligo and the effect Narrow band-UVB on IL-6 serum levels. Patients and Methods: The study included 30 patients with vitiligo and 30 healthy controls. Each was submitted to thorough history taking, complete general, dermatological examinations including VASI score, and assessment of serum interleukin-6 before and after 16 sessions of NB-UVB. Results: Results of this study showed no statistical significant difference between patients and control as regard age and gender. Our study revealed a statistically significant difference between levels of IL-6 in patients group before and after therapy. Conclusion: Knowing exactly the role of IL-6 is important not only to clarify the pathogenesis of this disease, but also to improve the clinical course of vitiligo (i.e., disease stabilization and/or repigmentation) and the quality-of-life of patients. |
| Databáze: | OpenAIRE |
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