Severe Permanent Encephalopathy in Acute Lymphoblastic Leukemia
| Autor: | Maureen Dennis, Bernard L. Maria, M.C. Obonsawin |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Pediatrics Obtundation business.industry Encephalopathy Induction chemotherapy Sequela General Medicine medicine.disease Chemotherapy regimen Surgery Leukemia Neurology Acute lymphocytic leukemia medicine Neurology (clinical) business Childhood Acute Lymphoblastic Leukemia |
| Zdroj: | Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 20:199-205 |
| ISSN: | 2057-0155 0317-1671 |
| DOI: | 10.1017/s0317167100047934 |
| Popis: | As survival rates for childhood acute lymphoblastic leukemia have increased, concerns over improved quality-of-life have also increased. Although 3-10% of children may experience acute transient neurotoxicity during induction chemotherapy, they are felt to be at low risk for late sequelae. We report three previously healthy boys with newly-diagnosed acute lymphoblastic leukemia who presented with obtundation and severe seizures during late induction with a standard four drug chemotherapy regimen. While all three are disease-free survivors, they unexpectedly have persistent and medically intractable partial complex seizures, broad-based neuropsychological impairment and striking neuroimaging abnormalities. These findings suggest that children with leukemia who develop an acute encephalopathy during induction chemotherapy are at risk for long-term neurological and neuropsychological sequelae, despite the cessation of further potentially neurotoxic therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|