The effect of transplantation of bone marrow or lymphocytes on the resistance of irradiated animals to diphtheria toxin

Autor: D R Kaulen
Rok vydání: 1962
Předmět:
Zdroj: Bulletin of Experimental Biology and Medicine. 52:1004-1007
ISSN: 1573-8221
0007-4888
Popis: Two experiments were staged on guinea pigs to investigate the effect produced by transplantation of the cells of homologous bone marrow and lymph nodes, in order to restore the natural resistance of the animals to diphteria toxin, reduced as a result of irradiation (200 r.). Both immunized and nonimmunized guinea pigs served as donors of the cells. Bone marrow was administered intravenously in a dose of 90–100.106 cells, lymphocytes−25.106 cells. As established, bone marrow cells raised the resistance of the animals to diphtheria toxin, reduced as a result of irradiation. The resistance index (I. R.) in the group of animals treated with ≪immune bone marrow≫ equals 0.87 and with the ≪nonimmune one≫ −0.69; in irradiated control animals it equalled 0.34; the resistance index of the normal animals was accepted as 1.0. Transplantation of lymphatic cells proved ineffective. It was impossible to detect any antitoxin in the recipients' blood, i.e. the transplanted cells produced no detectable amounts of the toxin.
Databáze: OpenAIRE
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