Electrocatalytic Detection of Uric Acid on Nitrogen-Doped Graphene Modified Electrode and Its Application
| Autor: | Wei Sun, Xiaoyan Li, Xueliang Niu, Hui Xie, Yong Cheng, Yaqi Huang, Lifeng Dong, Yongling Men |
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| Rok vydání: | 2017 |
| Předmět: |
Detection limit
Graphene Chemistry Analytical chemistry 02 engineering and technology General Chemistry Overpotential 010402 general chemistry 021001 nanoscience & nanotechnology Electrochemistry Electrocatalyst 01 natural sciences 0104 chemical sciences law.invention law Electrode Charge transfer coefficient Differential pulse voltammetry 0210 nano-technology |
| Zdroj: | Journal of the Chinese Chemical Society. 64:1360-1366 |
| ISSN: | 0009-4536 |
| DOI: | 10.1002/jccs.201700148 |
| Popis: | Nitrogen-doped graphene (NG) was used to modify a glassy carbon electrode (GCE), which was applied to the voltammetric detection of uric acid (UA). Because of the presence of NG on the GCE surface, the modified electrode showed excellent electrocatalytic ability for UA oxidation with increase of the peak current and decrease of the peak potential. Compared to that of the traditional GCE, the overpotential of the oxidation peak decreased by 50 mV. Electrochemical performance of UA was studied on NG/GCE in detail, which showed a quasi-reversible, diffusional-controlled process. Electrochemical parameters including the charge transfer coefficient (α), the number of electron transfer (n), and the diffusional coefficient (D) were calculated. At the optimal conditions, the oxidation peak current was linear, with UA concentration from 0.1 to 10.0 μmol/L as revealed by differential pulse voltammetry, and the detection limit was estimated as 0.042 μmol/L (3σ). The UA content in the urine sample of a healthy volunteer was determined by the proposed method with a recovery of 98.7–102.3%. |
| Databáze: | OpenAIRE |
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