Similarity of Insulin-Dependent Diabetics' and Non-Insulin-Dependent Diabetics' Levels of β-hCG and Unconjugated Estriol With Controls: No Need to Adjust as With Alpha-Fetoprotein
| Autor: | Eric L. Krivchenia, Arie Drugan, Joseph E. O’Brien, Mark I. Evans, Roderick F. Hume, Mark P. Johnson, Elena Dvorin |
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| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Pregnancy biology business.industry Insulin medicine.medical_treatment Obstetrics and Gynecology Estriol medicine.disease Endocrinology Internal medicine Diabetes mellitus medicine biology.protein business Alpha-fetoprotein hormones hormone substitutes and hormone antagonists ATP synthase alpha/beta subunits Mass screening Glycemic |
| Zdroj: | Journal of the Society for Gynecologic Investigation. 3:20-22 |
| ISSN: | 1071-5576 |
| Popis: | Objective To determine if the same systematic alteration of serum values seen for alpha-fetoprotein (AFP) in diabetic patients is also seen for beta-hCG and unconjugated estriol (uE3). Methods Serum AFP, beta-hCG, and uE3 results were obtained in 18,639 patients for whom complete follow-up information was obtained. Patients were divided into euglycemic (n = 18,088), insulin-requiring diabetics (n = 104), and non-insulin-requiring diabetics (n = 437), as well as by race. Results The 20% adjustment used for AFP appropriately corrects serum values. No such systematic variation is seen for either beta-hCG or uE3 by glycemic status or race. Conclusion No adjustment for beta-hCG or uE3 is necessary for diabetes for biochemical screening programs. |
| Databáze: | OpenAIRE |
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