ChemInform Abstract: Catalytic Arylation of a C-H Bond in Pyridine and Related Six-Membered N-Heteroarenes Using Organozinc Reagents

Autor:	Mamoru Tobisu, Naoto Chatani, Isao Hyodo
Rok vydání:	2012
Předmět:	chemistry.chemical_compound C h bond chemistry Nucleophile Pyrazine Reagent Pyridine Electrophile General Medicine Combinatorial chemistry Catalysis
Zdroj:	ChemInform. 43
ISSN:	0931-7597
Popis:	Despite significant advances in the catalytic direct arylation of heteroarenes, the application of this reaction to pyridines has been met with limited success. An oxidative nucleophilic arylation strategy has been developed to overcome this problem. Pyridine, pyrazine, quinolone, and related electron-deficient N-heteroarenes can be arylated at the most electrophilic site using the developed nickel-catalyzed reaction. This protocol serves as a complementary method to catalytic direct arylation reactions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::515d1b0c4a754630f61963b7ae41b849 https://doi.org/10.1002/chin.201241099 Zobrazit plný text záznamu Plný text