| Autor: |
Y. Yang, T. B. Martonen, D. Hwang, I. Katz, X. Guan |
| Rok vydání: |
1997 |
| Předmět: |
|
| Zdroj: |
Advances in Engineering Software. 28:359-364 |
| ISSN: |
0965-9978 |
| DOI: |
10.1016/s0965-9978(97)00014-8 |
| Popis: |
The primary pathological manifestation of cystic fibrosis (CF) is the obstruction by mucus of biological passages throughout the body. However, all patients will develop chronic obstructive lung disease which accounts for more than 90% of CF mortality. We have used the Cray Y-MP to develop a mathematical model for targeting the delivery of inhaled pharmacologic drugs in the treatment of respiratory tract diseases. The model consists of a three-dimensional description of the human lung, physiologically realistic airstream patterns, and a description of particle deposition processes. The supercomputer simulations demonstrate that the polydispersity of an aerosol, patient ventilatory parameters and disease-induced changes in airway structures can markedly alter the deposition patterns and, thereby, the inherent efficacies of pharmaceuticals. We submit that by using the model inhaled drugs can be delivered to appropriate sites within the lung to elicit optimum therapeutic effects. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect