Effect of topical heparin and levomenol on atopic dermatitis: a randomized four-arm, placebo-controlled, double-blind clinical study
| Autor: | Petr Arenberger, H. Drozenová, Monika Arenbergerova, S. Holcova, Marie Hladíková |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test Visual analogue scale business.industry Dermatology Heparin Atopic dermatitis medicine.disease Placebo Gastroenterology Double blind Clinical study Infectious Diseases Internal medicine medicine Itching SCORAD medicine.symptom business medicine.drug |
| Zdroj: | Journal of the European Academy of Dermatology and Venereology. 25:688-694 |
| ISSN: | 0926-9959 |
| Popis: | Background The aim of the controlled double-blind trial was to demonstrate the superiority of a topical combination product over its single constituents. Patients and Methods A total of 278 patients with atopic dermatitis were randomized into four groups: 79 patients were treated with a topical combination of levomenol and heparin (A), 80 patients with levomenol alone (B), 78 patients with heparin alone (C) and 41 patients with the cream base with no active substances (D). The medication was applied twice daily for 8 weeks. Efficacy criteria included the severity of pruritus (visual analogue scale, VAS) and the SCORing Atopic Dermatitis (SCORAD) index as well as the overall assessment of efficacy and tolerance by both physician and patient. Results The improvement of pruritus and SCORAD values in Group A was significantly higher compared with Groups B–D (ancova, P |
| Databáze: | OpenAIRE |
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