Efficient preparation method of 4-hydroxybenzoic esters – Oxidation of substituted Hagemman’s ester

Autor:	Sangho Koo, Sein Kang, Dahye Kim, Ik Joon In
Rok vydání:	2017
Předmět:	010405 organic chemistry Organic Chemistry Aromatization 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences Catalysis Preparation method chemistry.chemical_compound chemistry Ethyl acetoacetate Drug Discovery Organic chemistry Stoichiometry
Zdroj:	Tetrahedron Letters. 58:2264-2266
ISSN:	0040-4039
Popis:	A practical two-step synthetic method of diversely R-substituted 4-hydroxybenzoic esters, which may have wide applications in household chemicals and polymeric materials, was developed by 2:1 coupling between ethyl acetoacetate and aldehydes (RCHO) in t -BuOK/ t -BuOH, followed by oxidative aromatization of the resulting Hagemman’s esters. Application of the condition using stoichiometric NBS and catalytic TMS·OTf efficiently induced oxidation of the Hagemman’s esters to produce 4-hydroxybenzoic esters.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::514e9eaa05d5a4db8b39725acb664323 https://doi.org/10.1016/j.tetlet.2017.04.090 Zobrazit plný text záznamu Full Text from ScienceDirect