Electro-Acupuncture at GV.4 Improves Functional Recovery in paralyzed rats after a Traumatic Spinal Cord Injury
| Autor: | Alvarado Sanchez B, Salgado Ceballos H, Torres Castillo S, Juarez Becerril O, Anguiano Solis C, Diaz Ruiz A, Lopez Hernandez Me |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Traumatic spinal cord injury Electroacupuncture medicine.medical_treatment Electro acupuncture Stimulation medicine.disease_cause Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Paralysis medicine business.industry General Neuroscience Spinal cord 030104 developmental biology Anesthesiology and Pain Medicine medicine.anatomical_structure Complementary and alternative medicine chemistry Anesthesia medicine.symptom business 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Acupuncture & Electro-Therapeutics Research. 40:355-369 |
| ISSN: | 0360-1293 |
| DOI: | 10.3727/036012916x14533115160688 |
| Popis: | In the present study, the effect of electro-acupuncture (EA) on the oxidative stress, the spinal cord tissue preservation and the recovery of motor function was evaluated after a traumatic spinal cord injury (TSCI). Long Evans rats were randomized into five groups: 1. Sham; 2. TSCI without treatment; 3. TSCI + EA (acupoint GV.4); 4. TSCI + EA (acupoint GV.26) and 5. TSCI + EA (GV.4 + GV.26). The EA was performed with an Electro-Acupunctoscope, AWQ-104L Digital, wave dense-dispersed, current intensity 2.5mA and frequency 2-100Hz for 30 minutes. The biochemical results showed a significant increase in the hydroxyl radical concentration in group 2 (3.1±1.4nmol) compared with groups 1 (1.8±0.5nmol) and 4 (2.4±1.1nmol) (p2) than in groups 2 (5262.4±20μm2), 4 (3995.6±26μm2) and 5 (4266.7±22μm2). Although EA in GV.26 decreases hydroxyl radical concentration (50%), it significantly increases lipid peroxidation (45%), while stimulation of GV.4 decreases oxidative stress (15%), preserves spinal cord tissue (25%) and improves recovery of motor function in the hind limbs of rats with paralysis (18.1%) compared with untreated group. These findings suggest that EA in GV.4 may be a therapeutic alternative on TSCI. |
| Databáze: | OpenAIRE |
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