A new modification of the Passerini reaction: a one-pot synthesis of α-acyloxyamides via sequential Kornblum oxidation/Passerini reaction

Autor:	Mehdi Adib, Marjan Azimzadeh, Ehsan Sheikhi
Rok vydání:	2015
Předmět:	chemistry.chemical_compound Chemistry Dimethyl sulfoxide Organic Chemistry Drug Discovery One-pot synthesis Kornblum oxidation Halide Organic chemistry Biochemistry Passerini reaction
Zdroj:	Tetrahedron Letters. 56:1933-1936
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2015.02.007
Popis:	A novel approach for the synthesis of α-acyloxyamides is described. Benzylic substrates (halides or tosylates), under mild Kornblum conditions, are oxidized to give the corresponding aldehydes, which undergo a Passerini reaction with carboxylic acids and isocyanides to produce the corresponding α-acyloxyamides in excellent yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::512f5a42f249b46df0dc5c3c933f48fe https://doi.org/10.1016/j.tetlet.2015.02.007 Zobrazit plný text záznamu Full Text from ScienceDirect