Flavonoid glycosides from the fruit of Rhus parviflora and inhibition of cyclin dependent kinases by hyperin
| Autor: | Woo-Duck Seo, Hee-Cheol Kang, Seung-Woo Yeon, Jin-Gyeong Cho, Myun-Ho Bang, Yong-Jin Jeon, Ji-Hae Park, Sabina Shrestha, Nam-In Baek, Dae-Young Lee |
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| Rok vydání: | 2012 |
| Předmět: |
biology
Chemistry Stereochemistry Organic Chemistry Cyclin-dependent kinase 2 Infrared spectroscopy Fast atom bombardment Mass spectrometry General Biochemistry Genetics and Molecular Biology In vitro chemistry.chemical_compound Biochemistry Cyclin-dependent kinase Isoquercetin biology.protein Bioorganic chemistry |
| Zdroj: | Journal of the Korean Society for Applied Biological Chemistry. 55:689-693 |
| ISSN: | 2234-344X 1738-2203 |
| Popis: | Chrysoeriol-7-O-β-d-glucopyranoside (1), luteolin-7-O-β-d-glucopyranoside (2), quercetin-3-O-β-d-glucopyranoside (3), quercetin-3-O-β-d-galactopyranoside (4), and quercetin-3-O-α-l-rhamnopyranoside (5) were isolated for the first time from the fruits of Rhus parviflora. The chemical structures of the compounds were determined using nuclear magnetic resonance, fast atom bombardment mass spectrometry, and infrared spectroscopy. Compound 4 (hyperin) inhibited cyclin dependent kinases (CDK2 and CDK5) in vitro with IC50 values of 21.02 and 10.28 μM, respectively. |
| Databáze: | OpenAIRE |
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