Apocrine mixed tumor of the skin ('mixed tumor of the folliculosebaceous-apocrine complex')
| Autor: | Eduardo Calonje, Wayne Grayson, Dominic V. Spagnolo, Irena E. Belousova, Michal Michal, Dmitry V. Kazakov, Werner Kempf, M Hantschke, Bernhard Zelger, Michael Emberger, Michele Bisceglia, Susanna Virolainen, Heinz Kutzner |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Pathology
medicine.medical_specialty Mixed tumor Stromal cell Myoepithelial cell Apocrine Dermatology Biology medicine.disease Squamous metaplasia 3. Good health 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Collagenous spherulosis 030220 oncology & carcinogenesis Metaplasia medicine medicine.symptom Clear cell |
| Zdroj: | Journal of the American Academy of Dermatology. 57:467-483 |
| ISSN: | 0190-9622 |
| DOI: | 10.1016/j.jaad.2007.02.029 |
| Popis: | Background A systematic analysis of the entire spectrum of various forms of differentiation and metaplastic epiphenomena in cutaneous apocrine mixed tumor (AMT) has never been performed. Objective The purpose of our study was to study a large number of cutaneous mixed tumors so as to fully characterize the entire spectrum of differentiations and metaplastic changes that may occur in the epithelial, myoepithelial, and stromal components of AMT. Methods This article reports a light-microscopic study of 244 cases of cutaneous AMT, complemented by a literature review. Results All types of differentiation along the lines of the folliculosebaceous-apocrine unit can be seen in AMT. The spectrum of metaplastic changes in the epithelial components includes squamous metaplasia, mucinous metaplasia, oxyphilic metaplasia, clear cell change, columnar metaplasia, hobnail metaplasia, and cytoplasmic vacuolization. The following changes in the myoepithelial component were documented: clear cell change, hyaline cells, plasmacytoid cells, spindling, and collagenous spherulosis. Stromal alterations included chondroid metaplasia, osseous metaplasia, and adipose metaplasia. Limitations This study utilizes tissue specimens that mainly came as consultations; therefore some inherent selection bias exists. Conclusions AMT displays a wide range of differentiation and metaplastic changes in its epithelial, myoepithelial, and stromal components. These phenomena are not mutually exclusive. When unduly prominent, they may present diagnostic pitfalls. Our findings corroborate those of previous publications, stressing the remarkable diversity of differentiation and metaplasias that may be found in cutaneous AMT. We propose that the most appropriate name for these lesions is "mixed tumor of the folliculosebaceous-apocrine complex." |
| Databáze: | OpenAIRE |
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