Predictive performance of PAMG-1 vs fFN test for risk of spontaneous preterm birth in symptomatic women attending an emergency obstetric unit: retrospective cohort study
| Autor: | M. De Diego, Juan Carlos Melchor, M. Marcos, D. Rando, A. Iza, H. Navas, Iñigo Melchor, Jorge Burgos |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
030219 obstetrics & reproductive medicine Fetal fibronectin Radiological and Ultrasound Technology Preterm labor Obstetrics business.industry Medical record Obstetrics and Gynecology Retrospective cohort study General Medicine Test (assessment) 03 medical and health sciences 0302 clinical medicine Reproductive Medicine medicine Biomarker (medicine) Gestation Radiology Nuclear Medicine and imaging 030212 general & internal medicine business Risk assessment |
| Zdroj: | Ultrasound in Obstetrics & Gynecology. 51:644-649 |
| ISSN: | 0960-7692 |
| Popis: | OBJECTIVE To compare the performance of the placental alpha microglobulin-1 (PAMG-1) and fetal fibronectin (fFN) tests for the prediction of spontaneous preterm delivery in patients presenting to an emergency obstetric unit with threatened preterm labor, by conducting a retrospective audit of patient medical records from separate 1-year periods during which either fFN or PAMG-1 was used as the standard-of-care biochemical test. METHODS This was a retrospective cohort study based on chart review of electronic medical records of women with threatened preterm labor presenting at a level-III maternity hospital over two different periods: (1) the 'baseline' period (year 2012), during which the qualitative fFN test with a cut-off of 50 ng/mL was used as the standard-of-care biochemical test for the risk assessment of preterm delivery, and (2) the 'comparative' period (year 2016), during which the PAMG-1 test with a cut-off of 1 ng/mL was used as the standard-of-care biomarker test. Patients with a singleton pregnancy between 24 + 0 and 34 + 6 weeks' gestation with symptoms of early preterm labor, clinically intact membranes and cervical dilatation |
| Databáze: | OpenAIRE |
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