Genes Encoding Enzymatic Activities Implicated in the Eicosanoid Cascade of Arachidonic Acid and their Receptors are Expressed at mRNA Levels in Human Meningiomas
| Autor: | François Labrousse, Yves Denizot, Karine Durand, Nicolas Weinbreck, Rafael De Armas, Matias Pebet, Sandrine Robert, J.-J. Moreau |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Cancer Research
biology Thromboxane medicine.medical_treatment Prostacyclin Molecular biology chemistry.chemical_compound Cytokine Oncology chemistry Biochemistry Eicosanoid medicine biology.protein lipids (amino acids peptides and proteins) Arachidonic acid Cyclooxygenase Receptor Prostaglandin E medicine.drug |
| Zdroj: | Journal of Cancer Science & Therapy. |
| ISSN: | 1948-5956 |
| Popis: | In view of the important oncogenic action of lipoxygenase (LOX) and cycloxygenase (COX) enzymatic activities we investigated, by using real time PCR, their presence in human meningiomas. Results indicated the presence of 5-LOX, 12-LOX, 15-LOX1, 15-LOX2, COX-1, COX-2, prostaglandin E (PGE) synthase, prostacyclin (PGI) synthase and thromboxane (TX) synthase transcripts in meningiomas but without relation to the tumor grade, the subtype of meningiomas, the presence of inflammatory infiltrated cells, of an associated edema, mitosis, brain invasion, vascularisation or necrosis. Similar results were found for BLT1 and BLT2 transcripts (encoding LTB4 receptors) and for prostanoid receptor transcripts (EP1-4 for PGE2, IP for PGI2 and TP for TXA2). In conclusion, genes encoding enzymatic activities implicated in the eicosanoid cascade are expressed in meningiomas. LOX- and COX-derived arachidonic acid metabolites might act on tumor growth not only by acting on cell growth but also by altering the local cytokine and/ or angiogenic networks. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|